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Phosphorylation Anti-nociceptive tolerance induced by morphine, meperidine, and fentanyl was shown to be reduced by PKC inhibitors while DAMGO-induced tolerance and MOR desensitization was shown to rely on GRK (Hull et al., in vitro experiments showed that S375 is phosphorylated by GRK5 upon morphine exposure (Doll et al., 2004), S375A knock-in mice still present anti-nociceptive tolerance upon acute and chronic exposure to morphine (Grecksch et al., 2004

While generally well-tolerated, in high doses, such as 400 to 900 mcg/day, it can be harmful and even toxic

Jung, S

(2013, December 26)

Promotes Collagen Synthesis Studies show BPC-157 enhances growth hormone receptor expression in tendon fibroblasts, leading to increased collagen production