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The most common underlying respiratory diseases were bronchiectasis (79% vs 100%) and chronic obstructive pulmonary disease (COPD) (24.7% vs 33.0%)

Histological analysis revealed that anagen hair follicles in anti-VEGFtreated mice were thinner (Figure 5, c and d) with a more than 30% reduction in bulb diameters (Figure 5e), mainly due to reduced thickness of the follicular epithelium, associated with a significant, more than 40% decrease of perifollicular vascularization (Figure 5, f and g)