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Chronic hyperglycemia results in the suppressed activity of mTOR associated with AMP-activated protein kinase-induced increase in ROS formation and enhanced expression of thioredoxin interacting protein (TXNIP) a potential sensor of glucose and oxidative stress (Akpoveso et al

[DOI] [PMC free article] [PubMed] [Google Scholar] Tramutola A, Triplett JC, Di Domenico F, Niedowicz DM, Murphy MP, Coccia R, Perluigi M, Butterfield DA

Although the total number of seizures did not differ significantly between soman-exposed animals with or without SAR treatment (except at week 18), a shift in seizure severity was observed in the SAR-treated group