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Microarray studies using Affymetrix gene chips have demonstrated GHK-Cu resetting aging-related gene expression profiles in dermal fibroblasts, including upregulation of genes encoding superoxide dismutase (SOD1), metallothionein, collagen types I and III, and multiple anti-inflammatory interleukins

Assessing neurological symptoms: Vitamin B12 deficiency can cause neurological symptoms such as memory loss, balance problems, and even mood disturbances

In the US, levels of 0.1% (of the total product) are allowed

Pickart L, et al

However, degressive stockings are often considered difficult to put on, particularly in the elderly, and estimates of non-compliance with this method of compression range from 3065% (Couzan 2012