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[DOI] [PubMed] Rebouche C.J

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In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]

Following the previously described protocols, steps of coupling, washing and deprotecting are repeated to sequentially couple 5 equiv of Fmoc-L-Arg(Pbf)-OH (Fmoc-AA 5 -OH)

Moderate-to-high-intensity aerobic exercises, such as cycling or running, have been shown to reduce TMAO levels while also enhancing cardiovascular health