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doi: 10.1016/S0278-5846(96)00103-0 27

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The new regimen, which used half the dose of folinic acid of that used in the pilot study, resulted in significant increases in metabolites of the trans-sulphuration pathway as well as GSH:GSSG, although they remained below those of the control children

The SECIS selenocysteine (sec) insertion sequence represents mRNA and serves as a platform for the recruitment of Sec -ARNt translation stretching factors that decode the UGA codon for the incorporation of Se into selenoproteins [43]

However, it is crucial to ensure that the intracellular metabolites of interest are released from hepatocytes during the course of an hepatotoxic insult and remain stable in the blood, in order to be used as reliable biomarkers for the diagnosis and monitoring of DILI