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This resulted in eight genes for which individual knockouts led to differential expression of over one-hundred other genes following targeted library analysis, in response to radiotherapy

They significantly improve the uptake efficiency of polyphenols by increasing their solubility, facilitating their absorption through endocytosis, and promoting the entrapment or surface adsorption of biomolecules (116)

Table 2 summarizes some key molecular regulators involved in the functional transition from HIF-1 to HIF-2 under different hypoxic conditions

doi: 10.1016/j.molmed.2024.06.008 [DOI] [PubMed] [Google Scholar] 136

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