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We demonstrate the power and potential of this strategy for the preparation of various challenging targets in the efficient chemical syntheses of -conotoxin SI peptide, RANTES protein from the chemokine family, EETI-II trypsin inhibitor knotted mini protein, plectasin antimicrobial peptide and the linaclotide peptide drug

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Consistently, cell lines with abrogation of G2/M phase upon combination treatment, i.e., NCI-H520 and NCI-HCC15 also presented a reduction of the expression of p21 CIP/WAF1 and p-ATM, the latter involved in the DNA damage response pathway (Supplementary Figs