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It is known that TP could impair adjacent tissues through pro-inflammatory cytokines

iProX in 2021: connecting proteomics data sharing with big data

Although the role of LCN2 in downregulating SLC7A11 has not been extensively studied in depression, LCN2 upregulation and SLC7A11 downregulation were observed in streptozotocin (HFD-STZ)-induced mice, contributing to neuronal loss and cognitive dysfunction (Xie et al., 2023)