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Oligonucleotide microarray analysis followed by qPCR validation revealed the upregulation of miR-194 in LNCaP and PC3 cells, with direct targeting of bone morphogenetic protein 1 (BMP1) in the 3'-UTR region

Kameda M, Teruya T, Yanagida M, Kondoh H

And it's easy to doto just stop and say: Okay, you know what

Outcome measures include biomechanical testing (load to failure, stiffness), histological scoring (collagen organization, fibroblast density), and functional assessment (gait analysis, range of motion)

They have primarily focused on animal studies, without addressing the heterogeneity of results observed in clinical research and the underlying mechanisms, thus failing to provide more high-quality evidence