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Furthermore, programmed necrosis can also be influenced by ROS, which promote the formation of a stable association between two serine/threonine kinases, namely RIP1 and RIP3, which mediate the complex formation of programmed necrosis (Figure 1) (22, 24, 46, 47)

GHK-Cu is a naturally occurring copper complex that was initially discovered in human plasma but has since been detected in saliva and urine

The antioxidant glutathiones (ScienceDirect, 2023) Comprehensive presentation of the antioxidant functions of glutathione as a co-factor for enzymes and protection against oxidative stress

Consequently, this downregulation results in DNA damage and the subsequent production of DNA repair enzymes such as Poly-ADP Ribose Polymerase-1 (PARP-1), which inactivates glyceraldehyde-3-phosphate dehydrogenase (GAPDH), leading to the accumulation of glyceraldehyde-3-phosphate (GAP), Glucose 6-phosphate (G-6-P), and Fructose 6-phosphate (F-6-P)