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This predicts that the K D approach a plateau close to the value recorded for a single histidine residue when the linker is very long - and by extrapolation the ROS production would decrease similarly

Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43

doi: 10.1038/nrd1495 177 CiechomskaMRoszkowskiLMaslinskiW

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A novel vaccine using nanoparticle platform to present immunogenic M2e against avian influenza infection