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Cell viability was determined using the CellTiter-Glo Luminescent Cell Viability Assay (Promega, USA), on a Spark multimode microplate reader (TECAN, Switzerland) after 5 days

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Therefore, additional drugs for pancreatic cancer treatment can be developed by targeting BHLHE40 298

iPLA2-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

In vitro studies using mouse glioma models have shown that KD significantly reduces COX-2 expression, while combination studies with radiation therapy suggest decreased expression of COX-2 and other inflammatory markers