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Supplemental Figure 3

References 7784 show links between -synuclein, which genetics demonstrates is important in the progression of PD, and dopamine, which is required for the redox chemistry that is responsible for the oxidative stress

The choanoflagellates (Monosiga) do not encode RHD proteins, but the Amphimedon demosponge possesses one, thus, predating the appearance of numerous RHDs after the triploblast divergence