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Increased accumulation of DAG is inversely correlated with insulin sensitivity and is one of the factors causing the development of insulin resistance in skeletal muscle [141]

PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy

5-Hydroxytryptophan activates colonic myenteric neurons and propulsive motor function through 5-HT4 receptors in conscious mice

Melatonin has known, potent anti-oxidant, anti-inflammatory, and antitumor properties, but it also influences oncogenic pathways including mTOR, which plays a role in pancreatic cancer