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The proportions of patients who discontinued study drug in Study 2 were 9.3% and 13.8% for the 10 mg and 15 mg ZEPBOUND-treated groups, respectively, and 14.9% for the placebo-treated group

Trimethylamine-N-Oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway

Furthermore, recent integrative multiomics enhancer activity profiling revealed that a subgroup of patients, mostly with fluke-positive CCAs (many of cluster 1 tumours), exhibited increased oestrogen signalling activation and greater sensitivity to mTOR inhibitors

doi: 10.1371/journal.pbio.2002810

doi:10.1038/176325a0