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NLRP3 inflammasome (NLRP3 and caspase-1) modulate inflammatory processes via secretion of IL-1 and Th1 intensification (Figure 2)

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Two severe adverse events were reported: viral meningitis (in cagrilintide 1.2 mg + semaglutide 2.4 mg) and an increase in serum creatinine (in placebo + semaglutide 2.4 mg), but both events were deemed unrelated to study treatment by the study investigator

The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity