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This is a subtle but devastating failure point in research, leading to inconsistent or null results that are impossible to troubleshoot

It does not include a complete metabolic or optimization panel to establish baseline biomarkers

As far back as the 1970s, there were case reports in the literature of B12 deficiency associated with metformin use, with several observational studies reporting the same, but very little in the way of high-quality, well-powered, prospective studies

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