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SKU: 50418522608
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Pharmacologically, KEAP1 activity can be inhibited by the compound bardoxolone (CDDO) 68

In cancer cells, mitochondria overproduce reactive oxygen species (ROS), which contribute to cancer progression by inducing genomic instability, modifying gene expression, and participating in signaling pathways (72)

Yet, limitations in the experimental studies, as mentioned above, and the absence of clinical investigations hinder a conclusive determination of the beneficial role of IL-22 in the context of MASH