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Figure 2B shows the 1 H T relaxation times of the same formulations

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Clinically Important Drug Interactions with PPIs Reduced absorption due to gastric pH Azoles: Ketoconazole, Itraconazole, Posaconazole (oral) Antiretrovirals: Atazanavir , Rilpivirine Oral anticancer drugs (pH-dependent) Erlotinib, Gefitinib, Dasatinib, Nilotinib Iron salts, Calcium carbonate Mycophenolate mofetil Increased exposure / toxicity High-dose Methotrexate delayed clearance & toxicity Warfarin INR (monitor closely) Phenytoin, Diazepam Long-term safety concerns Hypomagnesemia (higher risk with diuretics) Clostridioides difficile infection Fracture risk with prolonged use Clinical Pearl Avoid unnecessary PPIs in patients receiving pH-dependent oral anticancer therapies

This scary fact shows we need to think carefully about supplements during chemo

Its because we have these tools weve built up at MIT over the years. They also synthesized a shorter sequence of only 12 amino acids found in the alpha helix, and then tested both of the peptides using equipment at MITs Biophysical Instrumentation Facility that can measure how strongly two molecules bind together