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Description

Additional biochemical assays were used to test the ability of compounds to inhibit nicotinamide phosphoribosyl transferase (NAMPT) and NAD + -dependent protein deacetylase sirtuin 1 (SIRT1), two enzymes in the NAD + biosynthesis/salvage pathway

Int J Stroke

In the multiple-ascending-dose arm at steady state (Day 28), the mean half-life increased to 48.1 to 67.5 hours across doses, reflecting the accumulation kinetics of a compound with nonlinear pharmacokinetics