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Low levels of ROS act as second messengers for activating inflammatory intracellular signaling, such as NF-B and MAP kinase pathways (30)

Tulubas F, Gurel A, Oran M, Topcu B, Caglar V, Uygur E (2015) The protective effects of -3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats

All data were analyzed using an Eppendorf Realplex 2

The Regulation of Ferroptosis GPX4 acts as a crucial downstream mediator of the amino acid transporter system x c , playing a vital role in ferroptosis regulation by reducing lipid hydroperoxides in membranes

89 It also induces a cytostatic effect on the cell cycle by deregulating extracellular signal-regulated protein kinases and subsequently suppressing cyclin E and cyclin-dependent kinase