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Nature (2010) 463:16970.10.1038/463169a 32 ChungW-SAllenNJErogluC

It is suggested that homocysteine not only promotes cellular and protein injury via oxidant mechanisms, but is also a marker for the presence of pathological oxidant stress.[30] Raised levels of homocysteine have been associated with an increased risk for many disorders Cystathionine beta-synthase (CBS) uses P5P as a cofactor to catalyse the reaction whereby homocysteine and serine combine to form cystathionine

This selective activity may support chondrocyte function and extracellular matrix synthesis while avoiding the complications associated with systemic growth hormone elevation

Electrolyte imbalance from stress develops from a relative excess of potassium, & a deficiency in sodium & magnesium

[DOI] [PMC free article] [PubMed] [Google Scholar] 226.Wang T., Wei J.J., Sabatini D.M., Lander E.S