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According to the Institute for Quality and Efficiency in Health Care (IQWiG), inflammation doesnt only start when, for instance, a wound has already been infected by bacteria

10.3892/mmr.2018.8674 163 WangR.LiY.-B.LiY.-H.XuY.WuH.-l.LiX.-J

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Nakhal M.M., Yassin L.K., Alyaqoubi R., Saeed S., Alderei A., Alhammadi A., Alshehhi M., Almehairbi A., Al Houqani S., BaniYas S., et al

Overall, analysis of the mice gut microbiome bacteria compositions supported that dysbiosis may play a role in the establishment and progression of disease in the chronic rotenone mouse models by mechanisms such as dysregulated glucose/lipid metabolism and inflammation

This leads to a loss of muscle mass, increase in fat deposition, loss of bone density, skin and hair integrity and other changes associated with aging