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Human mitochondrial DNA is a maternally inherited, circular genome approximately 16.6 kilobases in length that encodes 37 genes, including 13 polypeptides essential for oxidative phosphorylationcomprising subunits of complex I (NADH dehydrogenase), III (bc1 complex), IV (cytochrome c oxidase), and V (ATP synthase)as well as 22 transfer RNAs and the 12 S and 16 S ribosomal RNAs required for mitochondrial protein synthesis

The deficiency in COX2 proteins may contribute to the decreased mitochondrial respiration observed in BD iAstrocytes (Fig

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Biochim Biophys Acta Mol Cell Res 1866(8):12981309 Lee KW, Lee DJ, Lee JY, Kang DH, Kwon J, Kang SW (2011) Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair

Freshly prepared 50 mM N-(3-dimethylaminopropyl)-N-ethylcarbodiimide (in 1.5% pyridine, 98.5% ethanol, 21 L) and 140 mM 3-nitrophenylhydrazine (in 50% ethanol, 21 L) were added to each supernatant and incubated for 2 h, 37C