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A central reason to be cautious about oral glutathione supplements is a pharmacokinetic one: glutathione is a peptide, and peptides are broken down in the gastrointestinal tract

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Renal Impairment and Vitamin B12 Risks Patients with kidney problems need to be careful with vitamin B12 supplements

found that the mortality rate was 5.6% in critically ill patients with increased serum Cu concentrations and 50.0% in patients with decreased serum Cu concentrations after supplementation with standard trace elements for 2 weeks in critically ill patients (Lee et al., 2019)

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