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One final anchor for the regional definition

MIT Needle Free Technology injectors use CO2 or compressed air to propel a microjet of liquid six times the size of a 30-gauge needle through the skin

Typically, the diagnosis of IBD is established 8 to 10 years before the liver disease is evident, although there is no clear temporal association, and cases of IBD occurring years after diagnosis of PSC have also been reported (Chapman et al, 1980