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10.1073/pnas.1611406113 72 El-HattabA

Understanding these interorgan interactions is crucial for unraveling the mechanisms underlying health and disease

8-OHdG is produced when reactive oxygen species (ROS), specifically hydroxyl radicals, oxidize the guanine base in DNA, indicating oxidative DNA damage, that can be detected in circulation

The World Anti-Doping Agency (WADA) includes it under the category of S0 Non-approved Substances, which covers any pharmacological agent that has not been approved for human use by a regulatory authority

Besides inhibiting maconitase, zinc also induces apoptosis in prostate cancer cells via inhibition of NF-B, stimulation of caspases cascade, and induction of the cytochrome c from the mitochondria [87]