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Description

A total of 607 patients received pemetrexed, pembrolizumab, and platinum every 3 weeks for 4 cycles followed by pemetrexed and pembrolizumab (n=405), or placebo, pemetrexed, and platinum every 3 weeks for 4 cycles followed by placebo and pemetrexed (n=202)

10.1016/S8756-3282(02)00915-8 51

The deficiency is isolated to B12 without the need for multi-nutrient replenishment

Methods/design Study type This study takes the form a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting, with a duration of one year