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Davis V, Macvicar R, Ross C, Whitehair CK, Heidebrecht AA, Braude R, Coates ME, Henry KM, Kon SK, Thompson SY, Wilby F

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These validated proof-of-concept studies suggest that Ab-LNP-mediated delivery of CUL5-regulatory mRNA to enhance T-cell activation and proliferation may be feasible, although this remains to be experimentally demonstrated for CUL5 specifically

At the same time, resources from multiple disciplines, including nephrology, geriatrics, rehabilitation medicine, and nutrition, should be integrated to establish standardized assessment tools and early screening systems, thereby improving the overall prognosis for patients with CKD

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