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Hyperhomocysteinemia decreases GSH peroxidase activity leading to the prevalence of GSSG on GSH with the GSH/GSSG impaired ratio causing some common cardiovascular and neurodegenerative disorders (159)

By contrast, APEX2, also targeted to the cell surface, provided much weaker staining of the plasma membrane relative to intracellular organelles (Supplementary Fig

L-Glutathione helps combat oxidative stress and improve cellular function, while Vitamin C boosts the effectiveness of L-Glutathione, ensuring maximum antioxidant protection

The absorbance of the resulting solution was read at 700 nm with a Shimadzu spectrophotometer (UV min 1240, Shimadzu Corporation, Japan)