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Features Joint therapy approved by the FDA for both intravenous and intra-articular use, allowing treatment tailored to the veterinarian's preference and the horse's individual needs Millions of doses sold 5 More than 25 years of treatment success Safe and effective, proven by multiple studies Reduces production of inflammatory mediators, joint inflammation and the resulting lameness for at least 45 days after being given once a week for three weeks 4 Benefits Safe and effective 90% of cases treated intravenously judged to have excellent to good overall clinical improvement 1 96% of horses treated intra-articularly were judged to have excellent to good overall clinical improvement 1 Improvement can be seen after one dose Breaks the cycle of inflammation and lameness associated with synovitis Stimulates endogenous hyaluronic acid production 2 Decreases the presence of inflammatory mediators 4 Easy to use I.V

However, the polyphenols therapeutic potential is becoming more and more evident, enticing the worldwide researchers with a landscape of therapeutic possibilities to uncover the precise and effective biological role of this molecules in counteract oxidative stress, enabling their implementation in preventive healthcare practices, according to the evidence-based dentistry [168]

Neuroactive metabolites The gut microbiota synthesizes dopamine precursors (such as tyrosine metabolites) and gamma-aminobutyric acid (GABA), which directly affect the function of the nigro-striatum pathway

Serotonin syndrome signs and symptoms may include mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea)

Myung, S