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Reduced mitochondrial function, including decreased respiratory chain efficiency and impaired ATP production, likely contributes to increased ROS levels, oxidative damage, and diminished antioxidant protein synthesis

Differences in host genetics, demographic factors, social behaviors, circulating meningococcal strains, public health infrastructures, surveillance, and prophylactic interventions may explain differences in meningococcal epidemiology between different countries (Weckx et al., 2017

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If FRAT Is Negative A negative test can still be useful