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Furthermore, similar to the Rpc53 T228A strain, the kns1 mck1 double-knockout strain also resulted in a partial inhibition of Gcn4 induction (Supplementary Fig

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Mechanisms investigated Metabolic-pathway research converges on a small set of enzymatic and receptor targets, and these compounds map onto different ones they are not interchangeable: NNMT inhibition (5-Amino-1MQ): studied as a small-molecule inhibitor of nicotinamide N-methyltransferase, an enzyme implicated in cellular NAD/SAM metabolism

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