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Intracellular iron deposition is present and associated with these pathological features long before development (Goodman 1953

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia

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In AD, however, tau undergoes pathological hyperphosphorylation, leading to its dissociation from microtubules, aggregation into neurofibrillary tangles, and ultimately neuronal dysfunction (1)