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Targeting RAS-ERK pathway alterations with MEK inhibitors to improve chemosensitivity in high grade serous ovarian cancers

The expression of malondialdehyde (MDA) H 2 O 2 was significantly increased in the paw tissue of CIA mice, and intervention with curarelinone, the active ingredient of bitter ginseng, significantly inhibited oxidative damage and decreased the phosphorylation levels of signal transducer and activator of transcription (STAT)1, STAT3, and ratio of Th1 and Th17 cells in lymph nodes (62)

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This pattern suggests that divergence based on cofactor specificity is a major evolutionary feature of fungal GDHs, followed by lineage-specific diversification within fungal taxa

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