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Fourth, regarding the microbiota-lipid-depression mediation hypothesis, human intervention data are scarcemost evidence [e.g., (8890) on lipid transformation] comes from germ-free mouse models, but the diversity of the human gut microbiota (e.g., ~1,000 species vs

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70 This mechanism of action gives vedolizumab a favourable safety profile, as it does not have a systemic immunosuppressive effect