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This approach will clarify the activation levels of ERS markers and the duration of ERS in different cell types, such as neurons, oligodendrocytes, astrocytes, and microglia

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Mycotoxins such as ochratoxin, gliotoxin, and trichothecenes are known to: Disrupt lipid membranes Induce oxidative stress Alter immune signaling Affect central nervous system function In this case, both toxin burden and immune sensitization appeared to contribute to disease expression

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Thus, iron overload-induced ferroptosis significantly contributes to secondary injury in ICH, exacerbating oxidative stress and lipid peroxidation (Figure 2C)