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Patients report fatigue, joint stiffness, reduced exercise recovery, disrupted sleep architecture (particularly Stage 3 deep sleep, which is GH-dependent), and mood changes during the first 48 weeks post-cessation

Traditionally, these sweeteners have been assessed primarily for their effects on metabolic health, including glycemic control and weight management [1]

Among the most widely used mechanisms are reduction-sensitive disulfide (-SS-) and diselenide (-SeSe-) linkages, which can be cleaved by intracellular GSH to activate drug release or imaging functions [16]