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A significant increase in midazolam exposure (respectively from 3.02-fold to 26.41-fold for AUC and from 1.15-fold to 4.27-fold for C max ) in healthy volunteers concomitantly treated with ritonavir alone or ritonavir-boosted PIs has been reported, caused by strong inhibition of CYP3A4 [92,93,94,95]

Notably, non-oncogenic viruses, including both DNA and RNA viruses such as SARS-CoV-2, murine coronavirus (M-CoV), HSV-1, HHV-7, H1N1, and coxsackievirus B3 (CVB3), primarily enhance their replication within host cells by inducing ferroptosis, facilitating effective host infection

Safety profile and risk assessment FTPP carries more safety concerns than most peptides in the research space