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Ecotoxicol Environ Saf 75:151162 Orun I, Ates B, Selamoglu Z, Yazlak H, Ozturk E, Yilmaz I (2005) Effects of various sodium selenite concentrations on some biochemical and hematological parameters of rainbow trout ( Oncorhynchus mykiss )

Factors such as genetic predisposition, poor diet, smoking, and certain medical conditions can contribute to high homocysteine levels

Furthermore, achieving efficient delivery of Exos to affected tissues remains a major challenge

Interestingly, iron deficiency also aggravated RM-induced AKI by enhancing catalytic heme-iron-modulated lipid peroxidation and DNA oxidation, upregulating the activity of p53/p21 and promoting cellular senescence [162]

In this review, we discuss the role of cell death mechanisms and explore current frontiers in research, both in humans and animal models, including potential treatment opportunities