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KRAS also regulates TIAM1 and RAC1-specific guanine nucleotide exchange factors, to activate RAC1 signalling pathways that affect cell shape, migration, adhesion, actin cytoskeleton formation, endocytosis, and membrane trafficking 56

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30 per arm) would provide 80% power to detect a significant intraindividual change in total GSH of 12.5% (comparison baseline to end-of-treatment) and significant interindividual difference between groups (0 vs 2.4 vs

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