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The genes encoding the regulatory (GCLM) and catalytic (GCLC) subunits of -glutamylcysteinyl ligase, a rate-limiting enzyme for glutathione synthesis, are well known targets of Nrf2 (Moinova and Mulcahy, 1999

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Dual pH/light-responsive PEG-PDMAEMA-PNBAE micelles released curcumin at 46.5% under UV light at pH 5.5, protecting PC12 cells from A-induced apoptosis (138)

The sulfated conjugates of lithocholic acid also cannot be absorbed by the intestine, which results in their elimination from the pool of bile acids that circulate enterohepatically (of which more will be learned later)

Patients with sickle cell disease have increased sensitivity to cold and heat