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A variety of species express CD38, however, the caudate, pallidum, olfactory bulb, putamen, thalamus, and cingulate anterior of the human brain express CD38 at significantly higher levels than average [46]

It is important to note the regions of the brain that are more susceptible to the changes in BBB integrity as regions like the hippocampus and amygdala are heavily affected in neurodegenerative disease as they are vital for long-term memory and processing emotions and behavior

Aberrant oligodendroglial-vascular interactions disrupt the bloodbrain barrier, triggering CNS inflammation

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