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Methods: Using lentiviral integration, we created stable Huh-7 cell lines with WT and P446L GCKR overexpressed or knockdown using shRNAs

Methods: ALG-000184-201 is a multi-part, multi-center, double-blind, randomized, placebo-controlled Phase 1b study (NCT04536337) evaluating the safety, pharmacokinetic, and antiviral activity profiles of oral daily dosing with ALG-000184 in heathy volunteers (7 d) and subjects with chronic hepatitis B (48 weeks)

When the body becomes overwhelmed by too many CICs, the complexes accumulate in the liver, leading to impaired liver function

Transcriptomic reprogramming of rice cultivars in response to herbicide, salt and their combined stresses

The therapy is approved by the FDA and produced under strict quality control