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An exhaustive investigation revealed that an augmentation in ATF4, emanating from the mTORC2-PKC-Nrf2 signaling pathway, culminates in the induction of ATF4 expression and the promotion of Sirt5, a pivotal transcriptional target of ATF4

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Liposomal and sublingual forms often provide better bioavailability

It enables the cellular movement necessary for wound healing while also being implicated in cancer cell metastasis when the pathway becomes dysregulated

Notably, combination with anti-PD-1 checkpoint blockade yields synergy, significantly enhancing the ICB responsiveness of TNBC and producing improved therapeutic efficacy