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A review published in 2007 highlighted that metronidazole is effective against anaerobic bacteria and certain parasites starting from the first day of treatment

10.1107/S1744309110021688 6 ChristendatD.TurnbullJ

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Besides, a growing body of evidence shows that glutamate is able to regulate arteriole diameter, blood-brain barrier disruption and vasodilation (Sharp et al., 2003