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99,100,101 A study analysing 21 brain metastases and their matched primary breast cancer showed that BCBM tends to have high genomic-aberration-based-homologous recombination deficiency (HRD) scores compared with their primary tumour counterparts, which indicates that brain metastases might be more sensitive to PARP inhibitors than their corresponding primary tumours

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Finally, the model tells us that the loss of the N -selenoethyl side chain from SetCys peptide 2 is the rate-limiting step of SetCys-mediated ligation