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[310] A large prospective study reported a 20.3% prevalence of vitamin B12 deciency after 9.5 years of metformin use, [10] and a large dataset provided by the National Health and Nutrition Examination Survey showed a 22% prevalence when vitamin B12 deciency was dened as levels below 300 pg/mL

(weakness, lethargy, intolerance to cold, intestinal laziness, pale and dry skin, facial swelling, nail brittleness, hair loss, tongue enlargement, unexplained weight gain, muscle pain, tenderness, stiffness, joint pain and stiffness, muscle weakness, excessive and prolonged It comes with complaints such as menstrual bleeding or other menstrual irregularity, depression, memory problems, decreased exercise tolerance

They may: Promote lipolysis (fat breakdown) Increase metabolic efficiency Improve mitochondrial function 4