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3,21,40 However, good evidence is lacking on the appropriate timing of surgery and its associated outcomes when compared with medical therapies

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DNA methylation and MiRNA bidirectional feedback loop Positive regulation: DNA methylation silences tumor suppressor MiRNAs In drug-resistant cells, hypermethylation of tumor-suppressing miRNA promoters leads to their silencing, forming a positive feedback loop of DNA methylation/miRNA silencing/activation of drug resistance genes. For example, miR-130b is downregulated in cisplatin-resistant cells due to hypermethylation of its promoter

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We maybe should have anticipated that there would be more mixing or more structure than whats in textbooks, Bagenal says, noting that Jupiter could hold the key to understanding how other gas giant planets, including Saturn, work

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doi: 10.1046/j.1365-201x.2000.00596.x 173 WangDPengYXieYZhouBSunXKangRet al

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